Mesenchymal Stem/Stromal Cells as Biological Factories

A. B.B. Angulski, A. Correa, M. A. Stimamiglio

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Mesenchymal stem/stromal cells (MSCs) are factories of signaling molecules that affect diverse biological processes. MSCs respond to the microenvironment by releasing soluble factors that might regulate extracellular matrix remodeling as well as mitosis, angiogenesis, apoptosis, differentiation, and chemotaxis of target cells. The MSC secretome also modulates immune cells from innate and adaptive systems. MSCs might be considered as factories of extracellular vesicles (EVs) too. EVs include microvesicles, secreted by direct shedding of plasma membrane, and exosomes, formed inside the endosomal compartment and released to the milieu. MSC-EVs contain specific sets of molecules (lipids, proteins, nucleic acids) that function in cell-to-cell communication to maintain homeostasis and repair damaged tissues. These properties are under investigation in several disease models in trying to develop cell-free therapies for regenerative medicine. A caveat of these approaches is that MSC-EVs have anti- and protumorigenic activity. Much prudence and basic research is needed before these putative therapies reach the clinic.

Original languageEnglish (US)
Title of host publicationMesenchymal Stromal Cells as Tumor Stromal Modulators
PublisherElsevier Inc.
Pages65-101
Number of pages37
ISBN (Electronic)9780128031032
ISBN (Print)9780128031025
DOIs
StatePublished - Nov 18 2016
Externally publishedYes

Keywords

  • Cell-free therapy
  • Extracellular vesicles (EVs)
  • Mesenchymal stem/stromal cells (MSCs)
  • Paracrine activity
  • Secretome
  • Tissue repair

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