Mesenchymal stem or stromal cells

A review of clinical applications and manufacturing practices

Ratti Ram Sharma, Kathryn Pollock, Allison Hubel, David McKenna

Research output: Contribution to journalReview article

201 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have recently generated great interest in the fields of regenerative medicine and immunotherapy due to their unique biologic properties. In this review we attempt to provide an overview of the current clinical status of MSC therapy, primarily focusing on immunomodulatory and regenerative or tissue repair applications of MSCs. In addition, current manufacturing is reviewed with attention to variation in practices (e.g., starting material, approach to culture and product testing). There is considerable variation among the 218 clinical trials assessed here; variations include proposed mechanisms of action, optimal dosing strategy, and route of administration. To ensure the greatest likelihood of success in clinical trials as the field progresses, attention must be given to the optimization of MSC culture.

Original languageEnglish (US)
Pages (from-to)1418-1437
Number of pages20
JournalTransfusion
Volume54
Issue number5
DOIs
StatePublished - Jan 1 2014

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Mesenchymal Stromal Cells
Clinical Trials
Regenerative Medicine
Cell- and Tissue-Based Therapy
Immunotherapy
Cell Culture Techniques

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Mesenchymal stem or stromal cells : A review of clinical applications and manufacturing practices. / Sharma, Ratti Ram; Pollock, Kathryn; Hubel, Allison; McKenna, David.

In: Transfusion, Vol. 54, No. 5, 01.01.2014, p. 1418-1437.

Research output: Contribution to journalReview article

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