MERCURY AND MERCURIAL RESISTANCE DETERMINED BY PLASMIDS IN ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA.

Janet L Schottel, Amalendu Mandal, Kathleen Toth, Dan Clark, Simon Silver

Research output: Contribution to conferencePaperpeer-review

4 Scopus citations

Abstract

Resistance to mercuric chloride and to a wide variety of mercurial compounds including phenylmercuric acetate (PMA), methylmercuric chloride (MMC), merbromin and thimerosal is determined by genes on transmissible antibiotic transmissable resistance factors (R factors) in the enterics, staph and pseudomonads. Some plasmids determine resistance to mercuric acid alone while others determine resistance to a range of mercurials in addition to Hg(II). In more than 50 cases studied, mercury resistance is always associated with the ability to volatilize mercury from the medium. Where determined, the volatility mercury form is always metallic Hg(O): Hg(II) is reduced to Hg(O), PMA to Hg(O) plus benzene, and MMC to Hg(O) plus methane. The enzyme systems responsible are soluble rather than membrane bound and are produced only after induction of the cells by exposure to any of a variety of mercurials (generally, the range of inducers is wider than the range of substrates for the enzymes). Data are presented in graphical and tabular form.

Original languageEnglish (US)
Pages65-71
Number of pages7
StatePublished - Jan 1 1974
Externally publishedYes
EventInt Conf on Transp of Persistent Chem in Aquat Ecosyst, Proc - Ottawa, Ont, Can
Duration: May 1 1974May 3 1974

Other

OtherInt Conf on Transp of Persistent Chem in Aquat Ecosyst, Proc
CityOttawa, Ont, Can
Period5/1/745/3/74

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