TY - JOUR
T1 - Mental Health, Substance Use, and Related Factors Associated with Recent Use of Cannabis for Sleep
T2 - A Co-Twin Control Study
AU - Panchal, Zoë
AU - Sakai, Joseph
AU - Goldstein-Piekarski, Andrea N.
AU - Ellingson, Jarrod M.
AU - Iacono, William
AU - Corley, Robin P.
AU - Vrieze, Scott
AU - Hopfer, Christian J.
AU - Hewitt, John K.
AU - McGue, Matt K.
AU - Ross, J. Megan
N1 - Publisher Copyright:
© 2025 Taylor & Francis Group, LLC.
PY - 2025
Y1 - 2025
N2 - Objectives: To examine: 1) cross-sectional associations between past-month use of cannabis for sleep with mental health, substance use, and related factors in adults and 2) the role of genetic and early environmental factors shared by twins (familial confounds) in explaining significant associations. Methods: In a population-based sample of adult twins (n = 3,165, Mage36.7) we ran regression (phenotypic) and multilevel (co-twin control) models examining associations between past-month use of cannabis for sleep without comes of interest. We controlled for cannabis frequency and sleep quality except when each was the outcome of interest. Results: Recent use of cannabis for sleep was associated with multiple mental health, substance use, and related factors in phenotypic models. In co-twincontrol models, within-family effects were significant between using cannabis for sleep with more problems from cannabis use, higher cannabis frequency, worse sleep quality, and more frequent use of alcohol and medication for sleep. Conclusions: Familial confounds may explain many, but not all, associations between recent use of cannabis for sleep and mental health, substance use, and related factors. Longitudinal work is needed to clarify the directionality of associations not explained by familial confounds, and whether they are risks of using cannabis for sleep.
AB - Objectives: To examine: 1) cross-sectional associations between past-month use of cannabis for sleep with mental health, substance use, and related factors in adults and 2) the role of genetic and early environmental factors shared by twins (familial confounds) in explaining significant associations. Methods: In a population-based sample of adult twins (n = 3,165, Mage36.7) we ran regression (phenotypic) and multilevel (co-twin control) models examining associations between past-month use of cannabis for sleep without comes of interest. We controlled for cannabis frequency and sleep quality except when each was the outcome of interest. Results: Recent use of cannabis for sleep was associated with multiple mental health, substance use, and related factors in phenotypic models. In co-twincontrol models, within-family effects were significant between using cannabis for sleep with more problems from cannabis use, higher cannabis frequency, worse sleep quality, and more frequent use of alcohol and medication for sleep. Conclusions: Familial confounds may explain many, but not all, associations between recent use of cannabis for sleep and mental health, substance use, and related factors. Longitudinal work is needed to clarify the directionality of associations not explained by familial confounds, and whether they are risks of using cannabis for sleep.
UR - https://www.scopus.com/pages/publications/105006512732
UR - https://www.scopus.com/pages/publications/105006512732#tab=citedBy
U2 - 10.1080/15402002.2025.2508770
DO - 10.1080/15402002.2025.2508770
M3 - Article
C2 - 40400361
AN - SCOPUS:105006512732
SN - 1540-2002
VL - 23
SP - 648
EP - 660
JO - Behavioral Sleep Medicine
JF - Behavioral Sleep Medicine
IS - 5
ER -