@inproceedings{c90840b09f9f475d96c32b135b2b084b,
title = "MEMS for drug screening applications",
abstract = "MEMs sensors have the potential to serve as a low cost method for screening new drugs. To examine the feasibility of this technique, microbeams were designed such that an affinity between the beam surface (coated with a biomolecule) and a second biomolecule (simulating a potential drug) created a shift in the beam resonant frequency. PZT-actuated cantilever and bridge microbeams were fabricated and a baseline resonant frequency was established for each beam. Avidin and biotin were attached to the microbeams through a series of immersion and drying steps. Subsequent changes in the resonant frequency were recorded and compared for each beam. A drop in resonant frequency was consistently noted after the biotin molecule was introduced. To verify that the frequency shift could be attributed to the added mass of biotin, a biotin molecule with fluorescein dye was introduced. A direct correlation between fluorescent intensity and resonant frequency shift was observed.",
keywords = "Avidin, Biotin, Drug screening, Microbeam, Resonant frequency",
author = "J. Zhou and S. Z{\"u}rn and D. Markus and S. Mantell and D. Polla and G. Smith",
year = "2003",
language = "English (US)",
isbn = "0972842209",
series = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",
pages = "134--137",
editor = "M. Laudon and B. Romanowicz",
booktitle = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",
note = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003 ; Conference date: 23-02-2003 Through 27-02-2003",
}