MEMS for drug screening applications

J. Zhou, S. Zürn, D. Markus, S. Mantell, D. Polla, G. Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MEMs sensors have the potential to serve as a low cost method for screening new drugs. To examine the feasibility of this technique, microbeams were designed such that an affinity between the beam surface (coated with a biomolecule) and a second biomolecule (simulating a potential drug) created a shift in the beam resonant frequency. PZT-actuated cantilever and bridge microbeams were fabricated and a baseline resonant frequency was established for each beam. Avidin and biotin were attached to the microbeams through a series of immersion and drying steps. Subsequent changes in the resonant frequency were recorded and compared for each beam. A drop in resonant frequency was consistently noted after the biotin molecule was introduced. To verify that the frequency shift could be attributed to the added mass of biotin, a biotin molecule with fluorescein dye was introduced. A direct correlation between fluorescent intensity and resonant frequency shift was observed.

Original languageEnglish (US)
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages134-137
Number of pages4
StatePublished - 2003
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Publication series

Name2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume1

Other

Other2003 Nanotechnology Conference and Trade Show - Nanotech 2003
CountryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Keywords

  • Avidin
  • Biotin
  • Drug screening
  • Microbeam
  • Resonant frequency

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