Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease

Sarah E. Cook; Robert D. Nebes; Edythe M. Halligan; Lynn A. Burmeister; Judith A. Saxton; Mary Ganguli; Melanie B. Fukui; Carolyn C. Meltzer; Robert L. Williams; Steven T. DeKosky

doi:10.1076/anec.9.3.175.9610

Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease

Sarah E. Cook, Robert D. Nebes, Edythe M. Halligan, Lynn A. Burmeister, Judith A. Saxton, Mary Ganguli, Melanie B. Fukui, Carolyn C. Meltzer, Robert L. Williams, Steven T. DeKosky

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Abstract

This study examined whether a mild elevation in serum Thyroid Stimulating Hormone (TSH) in normal older individuals was associated with a cognitive impairment. Participants consisted of 15 individuals with a high-TSH level and 82 with a normal TSH. The high-TSH group performed significantly worse than the normal-TSH group of tests of immediate and delayed verbal recall and on the Mini-Mental State Exam. This decrement was not due to group differences in processing resources nor was it explained by comorbid cerebrovascular disease, depression or anticholinergic drug usage. These results suggest that undetected mild thyroid dysfunction may contribute to the cognitive decrements found in older adults.

Original language	English (US)
Pages (from-to)	175-183
Number of pages	9
Journal	Aging, Neuropsychology, and Cognition
Volume	9
Issue number	3
DOIs	https://doi.org/10.1076/anec.9.3.175.9610
State	Published - Sep 2002

Bibliographical note

Funding Information:
This work was supported by grants from the National Institute on Aging (AG 14051; AG 05133) and the National Institute of Mental Health (MH52247).

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Cook, S. E., Nebes, R. D., Halligan, E. M., Burmeister, L. A., Saxton, J. A., Ganguli, M., Fukui, M. B., Meltzer, C. C., Williams, R. L., & DeKosky, S. T. (2002). Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease. Aging, Neuropsychology, and Cognition, 9(3), 175-183. https://doi.org/10.1076/anec.9.3.175.9610

Cook, SE, Nebes, RD, Halligan, EM, Burmeister, LA, Saxton, JA, Ganguli, M, Fukui, MB, Meltzer, CC, Williams, RL & DeKosky, ST 2002, 'Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease', Aging, Neuropsychology, and Cognition, vol. 9, no. 3, pp. 175-183. https://doi.org/10.1076/anec.9.3.175.9610

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abstract = "This study examined whether a mild elevation in serum Thyroid Stimulating Hormone (TSH) in normal older individuals was associated with a cognitive impairment. Participants consisted of 15 individuals with a high-TSH level and 82 with a normal TSH. The high-TSH group performed significantly worse than the normal-TSH group of tests of immediate and delayed verbal recall and on the Mini-Mental State Exam. This decrement was not due to group differences in processing resources nor was it explained by comorbid cerebrovascular disease, depression or anticholinergic drug usage. These results suggest that undetected mild thyroid dysfunction may contribute to the cognitive decrements found in older adults.",

author = "Cook, {Sarah E.} and Nebes, {Robert D.} and Halligan, {Edythe M.} and Burmeister, {Lynn A.} and Saxton, {Judith A.} and Mary Ganguli and Fukui, {Melanie B.} and Meltzer, {Carolyn C.} and Williams, {Robert L.} and DeKosky, {Steven T.}",

note = "Funding Information: This work was supported by grants from the National Institute on Aging (AG 14051; AG 05133) and the National Institute of Mental Health (MH52247).",

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AU - Saxton, Judith A.

AU - Ganguli, Mary

AU - Fukui, Melanie B.

AU - Meltzer, Carolyn C.

AU - Williams, Robert L.

AU - DeKosky, Steven T.

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AB - This study examined whether a mild elevation in serum Thyroid Stimulating Hormone (TSH) in normal older individuals was associated with a cognitive impairment. Participants consisted of 15 individuals with a high-TSH level and 82 with a normal TSH. The high-TSH group performed significantly worse than the normal-TSH group of tests of immediate and delayed verbal recall and on the Mini-Mental State Exam. This decrement was not due to group differences in processing resources nor was it explained by comorbid cerebrovascular disease, depression or anticholinergic drug usage. These results suggest that undetected mild thyroid dysfunction may contribute to the cognitive decrements found in older adults.

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Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease

Abstract

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