Membrane properties of dolichol in different age groups of mice

W. Gibson Wood, Grace Y. Sun, Friedhelm Schroeder

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Dolichol content and the effects of dolichol in vitro on synaptic plasma membrane (SPM) structure of different age groups of C57BL/6NNIA mice were examined. SPM of aged mice had higher amounts of dolichol as compared to younger animals. Age differences also were observed in dolichol isoprenologue distribution. In older animals, dolichol isoprenologue chain length was shifted towards shorter chain length values. The structure of SPM was determined by differential polarized phase fluorometry of 1,6-diphenyl-1,3,5-hexatriene (DPH). The SPM of old mice were more rigid, as indicated by higher limiting anisotropy, than those of young mice. Dolichol administered in vitro to SPM fluidized the membranes. However, dolichol administered in vitro fluidized SPM of younger mice significantly more than SPM of aged mice. The functional role of increased dolichol content in aged individuals is not known. Dolichol may act to regulate membrane fluidity of aged animals.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalChemistry and Physics of Lipids
Volume51
Issue number3-4
DOIs
StatePublished - Nov 1989

Keywords

  • aging
  • dolichol
  • fluidity
  • lipids
  • membranes

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