Membrane organization in immunoglobulin E receptor signaling

Erin D. Sheets, David Holowka, Barbara Baird

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

The structure and dynamics of the plasma membrane are proposed to be critical for the initial steps of signal transduction by the high-affinity immunoglobulin E receptor. Recent experimental advances indicate that interactions between the high-affinity immunoglobulin E receptor and the tyrosine kinase Lyn with cholesterol- and sphingolipid-rich regions within the plasma membrane are important for receptor function. This accumulating evidence points to spatio-temporal control of immunoglobulin E receptor signaling by the organization of the plasma membrane; an attractive hypothesis is that ligand-dependent receptor aggregation causes the segregation of Lyn-containing ordered regions of the plasma membrane from disordered regions.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalCurrent opinion in chemical biology
Volume3
Issue number1
DOIs
StatePublished - Feb 1 1999

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