Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

Franck Mauvais-Jarvis; Carol A. Lange; Ellis R. Levin

doi:10.1210/endrev/bnab041

Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

Franck Mauvais-Jarvis, Carol A. Lange, Ellis R. Levin

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein synthesis. This led to the paradigm that steroid hormones regulate growth, differentiation, and metabolism via binding a receptor in the nucleus. It took 30 years to appreciate not only that some cellular functions arise solely from membrane-localized steroid receptor (SR) actions, but that rapid sex steroid signaling from membrane-localized SRs is a prerequisite for the phosphorylation, nuclear import, and potentiation of the transcriptional activity of nuclear SR counterparts. Here, we provide a review and update on the current state of knowledge of membrane-initiated estrogen (ER), androgen (AR) and progesterone (PR) receptor signaling, the mechanisms of membrane-associated SR potentiation of their nuclear SR homologues, and the importance of this membrane-nuclear SR collaboration in physiology and disease. We also highlight potential clinical implications of pathway-selective modulation of membrane-associated SR.

Original language	English (US)
Pages (from-to)	720-742
Number of pages	23
Journal	Endocrine reviews
Volume	43
Issue number	4
DOIs	https://doi.org/10.1210/endrev/bnab041
State	Published - Aug 1 2022

Bibliographical note

Funding Information:
Financial Support: This work was supported by National Institutes of Health awards DK107444 and DK074970 (F.M.J.), CA159712 (C.A.L.), U.S. Department of Veterans Affairs Merit Awards BX003725 (F.M.J.) and BX002316 (E.R.L.) and the Tulane Center of Excellence in Sex-Based Biology & Medicine.

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

Keywords

androgen
estrogen
nongenomic
progesterone
rapid actions
Receptors, Steroid/metabolism
Estrogens
Humans
Progesterone/physiology
Estradiol
Receptors, Androgen
Androgens
Receptors, Progesterone/metabolism
Steroids

PubMed: MeSH publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/endrev/bnab041

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abstract = "Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein synthesis. This led to the paradigm that steroid hormones regulate growth, differentiation, and metabolism via binding a receptor in the nucleus. It took 30 years to appreciate not only that some cellular functions arise solely from membrane-localized steroid receptor (SR) actions, but that rapid sex steroid signaling from membrane-localized SRs is a prerequisite for the phosphorylation, nuclear import, and potentiation of the transcriptional activity of nuclear SR counterparts. Here, we provide a review and update on the current state of knowledge of membrane-initiated estrogen (ER), androgen (AR) and progesterone (PR) receptor signaling, the mechanisms of membrane-associated SR potentiation of their nuclear SR homologues, and the importance of this membrane-nuclear SR collaboration in physiology and disease. We also highlight potential clinical implications of pathway-selective modulation of membrane-associated SR.",

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author = "Franck Mauvais-Jarvis and Lange, {Carol A.} and Levin, {Ellis R.}",

note = "Funding Information: Financial Support: This work was supported by National Institutes of Health awards DK107444 and DK074970 (F.M.J.), CA159712 (C.A.L.), U.S. Department of Veterans Affairs Merit Awards BX003725 (F.M.J.) and BX002316 (E.R.L.) and the Tulane Center of Excellence in Sex-Based Biology & Medicine. Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.",

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KW - progesterone

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KW - Receptors, Steroid/metabolism

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KW - Progesterone/physiology

KW - Estradiol

KW - Receptors, Androgen

KW - Androgens

KW - Receptors, Progesterone/metabolism

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Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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