Abstract
The interaction of Abeta with synaptosomal plasma membranes decreases membrane fluidity. Using model membrane/liposome systems the interaction of Abeta with specific lipids (e.g. phospholipids, gangliosides, cholesterol) has been defined. The formation of the beta-sheet structure of Abeta when undergoing peptide aggregation is important for Abeta's membrane perturbing properties. This effect can be correlated with the peptide length of Abeta, the longer Abeta1-42 having the greatest effect on membrane fluidity and on neurotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 319-337 |
| Number of pages | 19 |
| Journal | Sub-Cellular Biochemistry |
| Volume | 38 |
| State | Published - 2005 |