Membrane disordering effects of beta-amyloid peptides.

Gunter P. Eckert, W. Gibson Wood, W. E. Müller

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The interaction of Abeta with synaptosomal plasma membranes decreases membrane fluidity. Using model membrane/liposome systems the interaction of Abeta with specific lipids (e.g. phospholipids, gangliosides, cholesterol) has been defined. The formation of the beta-sheet structure of Abeta when undergoing peptide aggregation is important for Abeta's membrane perturbing properties. This effect can be correlated with the peptide length of Abeta, the longer Abeta1-42 having the greatest effect on membrane fluidity and on neurotoxicity.

Original languageEnglish (US)
Pages (from-to)319-337
Number of pages19
JournalSub-Cellular Biochemistry
StatePublished - 2005


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