Melt Processing of Chitosan-Based Fibers and Fiber-Mesh Scaffolds for the Engineering of Connective Tissues

Vitor M. Correlo, Ana R. Costa-Pinto, Paula Sol, José A. Covas, Mrinal Bhattacharya, Nuno M. Neves, Rui L. Reis

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We report the production of chitosan-based fibers and chitosan fiber-mesh structures by melt processing (solvent-free) to be used as tissue-engineering scaffolds. The melt-based approach used to produce the scaffolds does not change their main characteristics, including the surface roughness and microporosity. The porosity, pore size, interconnectivity and mechanical performance of the scaffolds are all within the range required for various tissue-engineering applications. Biological assessments are performed in direct-contact assays. Cells are able to colonize the scaffold, including the inner porous structure. The cells show high indices of viability in all of the scaffold types.The production of chitosan-based fibers and chitosan fiber-mesh structures by totally solvent-free melt processing is reported: most of the methods proposed to produce chitosan-based scaffolds have been based on the use of solvents. After being submitted to morphological, mechanical and biological tests, the scaffolds show properties of great interest towards the engineering of connective tissues.

Original languageEnglish (US)
Pages (from-to)1495-1504
Number of pages10
JournalMacromolecular Bioscience
Volume10
Issue number12
DOIs
StatePublished - Dec 13 2010

Keywords

  • Chitosan
  • Fiber mesh
  • Osteoblasts
  • Scaffolds
  • Tissue engineering

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