TY - JOUR
T1 - Melanoma chemoprevention
AU - Francis, Shayla O.
AU - Mahlberg, Matthew J.
AU - Johnson, Kathryn R.
AU - Ming, Michael E.
AU - Dellavalle, Robert P.
PY - 2006/11
Y1 - 2006/11
N2 - Background: Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures. Objective: We sought to summarize the results of published research on candidate chemoprevention agents for melanoma. Methods: We conducted a narrative review of the literature. Results: Investigation into a possible role in melanoma chemoprevention continues for multiple agents, including sunscreen, lipid-lowering medications, nonsteroidal anti-inflammatory drugs, dietary nutrients, immunomodulators, and other drugs, including retinoids, difluoromethylornithine, and T4 endonuclease V. Limitations: Systematic review of the literature was not performed. Conclusion: Because no agent yet emerges as a clear choice for effective melanoma chemoprevention, sun avoidance and sun protection remain the mainstay of melanoma prevention for persons at high risk.
AB - Background: Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures. Objective: We sought to summarize the results of published research on candidate chemoprevention agents for melanoma. Methods: We conducted a narrative review of the literature. Results: Investigation into a possible role in melanoma chemoprevention continues for multiple agents, including sunscreen, lipid-lowering medications, nonsteroidal anti-inflammatory drugs, dietary nutrients, immunomodulators, and other drugs, including retinoids, difluoromethylornithine, and T4 endonuclease V. Limitations: Systematic review of the literature was not performed. Conclusion: Because no agent yet emerges as a clear choice for effective melanoma chemoprevention, sun avoidance and sun protection remain the mainstay of melanoma prevention for persons at high risk.
UR - http://www.scopus.com/inward/record.url?scp=33749684978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749684978&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2006.04.014
DO - 10.1016/j.jaad.2006.04.014
M3 - Review article
C2 - 17052492
AN - SCOPUS:33749684978
SN - 0190-9622
VL - 55
SP - 849
EP - 861
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -
