Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.
Bibliographical noteFunding Information:
This research was financially supported by a grant (R01-2007-000-20099-0) from the National Research Foundation of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.
- Angelica koreana
- Bisabolane-type sesquiterpenoid
- Melanogenesis inhibitor