Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B                         12                          Metabolism: Case Reports and Literature Review

Dolores Mullikin; Nishitha Pillai; Rossana Sanchez; Anne H. O'Donnell- Luria; Amy Kritzer; Leyat Tal; Mohammed Almannai; Gerard T. Berry; Michael J. Gambello; Hong Li; Brett Graham; Lakshmi Srivaths; Vernon Reid Sutton; Amanda Grimes

doi:10.1016/j.jpeds.2018.06.054

Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review

Dolores Mullikin
, Nishitha Pillai
, Rossana Sanchez
, Anne H. O'Donnell- Luria
, Amy Kritzer
, Leyat Tal
, Mohammed Almannai
, Gerard T. Berry
, Michael J. Gambello
, Hong Li
, Brett Graham
, Lakshmi Srivaths
, Vernon Reid Sutton
, Amanda Grimes

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We describe 2 children with cobalamin G disease, a disorder of vitamin B ₁₂ metabolism with normal serum B ₁₂ levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

Original language	English (US)
Pages (from-to)	315-319.e2
Journal	Journal of Pediatrics
Volume	202
DOIs	https://doi.org/10.1016/j.jpeds.2018.06.054
State	Published - Nov 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Cobalamin G disease
Coblamain C disease
hyperhomocysteinemia
megaloblastic anemia
methionine synthase
thrombotic microangiopathy

Publisher link

10.1016/j.jpeds.2018.06.054

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Cite this

Mullikin, D., Pillai, N., Sanchez, R., O'Donnell- Luria, A. H., Kritzer, A., Tal, L., Almannai, M., Berry, G. T., Gambello, M. J., Li, H., Graham, B., Srivaths, L., Sutton, V. R., & Grimes, A. (2018). Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review. Journal of Pediatrics, 202, 315-319.e2. https://doi.org/10.1016/j.jpeds.2018.06.054

Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review. / Mullikin, Dolores; Pillai, Nishitha; Sanchez, Rossana et al.
In: Journal of Pediatrics, Vol. 202, 11.2018, p. 315-319.e2.

Research output: Contribution to journal › Article › peer-review

Mullikin, D, Pillai, N, Sanchez, R, O'Donnell- Luria, AH, Kritzer, A, Tal, L, Almannai, M, Berry, GT, Gambello, MJ, Li, H, Graham, B, Srivaths, L, Sutton, VR & Grimes, A 2018, 'Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review', Journal of Pediatrics, vol. 202, pp. 315-319.e2. https://doi.org/10.1016/j.jpeds.2018.06.054

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title = "Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B 12 Metabolism: Case Reports and Literature Review",

abstract = " We describe 2 children with cobalamin G disease, a disorder of vitamin B 12 metabolism with normal serum B 12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.",

keywords = "Cobalamin G disease, Coblamain C disease, hyperhomocysteinemia, megaloblastic anemia, methionine synthase, thrombotic microangiopathy",

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AU - O'Donnell- Luria, Anne H.

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AU - Almannai, Mohammed

AU - Berry, Gerard T.

AU - Gambello, Michael J.

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KW - megaloblastic anemia

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