Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B 12 Metabolism: Case Reports and Literature Review

Dolores Mullikin, Nishitha Pillai, Rossana Sanchez, Anne H. O'Donnell- Luria, Amy Kritzer, Leyat Tal, Mohammed Almannai, Gerard T. Berry, Michael J. Gambello, Hong Li, Brett Graham, Lakshmi Srivaths, Vernon Reid Sutton, Amanda Grimes

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We describe 2 children with cobalamin G disease, a disorder of vitamin B 12 metabolism with normal serum B 12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

Original languageEnglish (US)
Pages (from-to)315-319.e2
JournalJournal of Pediatrics
Volume202
DOIs
StatePublished - Nov 2018
Externally publishedYes

Keywords

  • Cobalamin G disease
  • Coblamain C disease
  • hyperhomocysteinemia
  • megaloblastic anemia
  • methionine synthase
  • thrombotic microangiopathy

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    Mullikin, D., Pillai, N., Sanchez, R., O'Donnell- Luria, A. H., Kritzer, A., Tal, L., Almannai, M., Berry, G. T., Gambello, M. J., Li, H., Graham, B., Srivaths, L., Sutton, V. R., & Grimes, A. (2018). Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B 12 Metabolism: Case Reports and Literature Review. Journal of Pediatrics, 202, 315-319.e2. https://doi.org/10.1016/j.jpeds.2018.06.054