Medium-chain fatty acid nanoliposomes for easy energy supply

Wei Liu; Wei Lin Liu; Cheng Mei Liu; Jian Hua Liu; Shui Bing Yang; Hui Juan Zheng; Han Wu Lei; Roger Ruan; Ti Li; Zong Cai Tu; Xin Yong Song

doi:10.1016/j.nut.2010.06.010

Medium-chain fatty acid nanoliposomes for easy energy supply

Wei Liu, Wei Lin Liu, Cheng Mei Liu, Jian Hua Liu, Shui Bing Yang, Hui Juan Zheng, Han Wu Lei, Roger Ruan, Ti Li, Zong Cai Tu, Xin Yong Song

Bioproducts and Biosystems Engineering

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Objective: Developing a nanoliposome delivery system for an easy energy supply of medium-chain fatty acids (MCFAs) to improve oral doses and bioavailability. Methods: Bangham's method and high-pressure microfluidization were used to prepare MCFA liposomes. The easy energy-supply property of MCFA nanoliposomes was estimated by the anti-fatigue experiments of mice including a weight-loaded swimming test and its corresponding parameters (serum urea nitrogen, blood lactic acid, and hepatic glycogen). For comparison, nanoliposomes without MCFAs and MCFAs not entrapped in nanoliposomes were used throughout. Results: Compared with crude MCFA liposomes according to Bangham's method, the MCFA nanoliposomes made by high-pressure microfluidization exhibited great advantages in their characteristics, with a small average diameter (76.2 ± 34.7 nm), narrow size distribution (polydispersity index 0.207), high ζ-potential (-50.51 mV), great entrapment efficiency (70.5%) and drug loading (9.4%), and good stability. The high-dose group and the MCFA group (680 mg/kg) showed a longer weight-loaded swimming time (104 ± 29 min, P = 0.087, and 108 ± 11 min, P = 0.047, respectively) and significantly higher hepatic glycogen (16.40 ± 1.45 mg/g, P < 0.001 and 17.27 ± 2.13 mg/g, P < 0.001, respectively) than the control group (59 ± 11 min and 8.79 ± 2.76 mg/g, respectively). Moreover, serum urea nitrogen (891.5 ± 113.4 mg/L, P = 0.024, and 876.6 ± 70.8 mg/L, P = 0.015, respectively) and blood lactic acid (6.05 ± 1.40 mmol/L, P = 0.001, and 5.95 ± 1.27 mmol/L, P < 0.001, respectively) in the high-dose group and the group with an equivalent MCFA dose were significantly lower than those in the control group (1153.6 ± 102.5 mg/L and 12.53 ± 1.86 mmol/L, respectively). Conclusion: Similar to MCFAs, MCFA nanoliposomes prepared by high-pressure microfluidization showed a strong easy energy-supply property, which suggested that MCFA nanoliposomes could be a potential drug candidate for an easy energy supply.

Original language	English (US)
Pages (from-to)	700-706
Number of pages	7
Journal	Nutrition
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.nut.2010.06.010
State	Published - Jun 2011

Bibliographical note

Funding Information:
This research was supported by the National High Technology Research and Development Program of China (863 Program, grant 2007AA100403 ), the Key Project of “863” (grant 2008AA10Z330 ), and the Objective-Oriented Project of the State Key Laboratory of Food Science and Technology, Nanchang University (grant SKLF-MB-200808 ).

Keywords

Easy energy supply
High-pressure microfluidization
Medium-chain fatty acids
Nanoliposomes
Stability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.nut.2010.06.010

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@article{27ee5250a4a742928799ea52b9446ba2,

title = "Medium-chain fatty acid nanoliposomes for easy energy supply",

abstract = "Objective: Developing a nanoliposome delivery system for an easy energy supply of medium-chain fatty acids (MCFAs) to improve oral doses and bioavailability. Methods: Bangham's method and high-pressure microfluidization were used to prepare MCFA liposomes. The easy energy-supply property of MCFA nanoliposomes was estimated by the anti-fatigue experiments of mice including a weight-loaded swimming test and its corresponding parameters (serum urea nitrogen, blood lactic acid, and hepatic glycogen). For comparison, nanoliposomes without MCFAs and MCFAs not entrapped in nanoliposomes were used throughout. Results: Compared with crude MCFA liposomes according to Bangham's method, the MCFA nanoliposomes made by high-pressure microfluidization exhibited great advantages in their characteristics, with a small average diameter (76.2 ± 34.7 nm), narrow size distribution (polydispersity index 0.207), high ζ-potential (-50.51 mV), great entrapment efficiency (70.5%) and drug loading (9.4%), and good stability. The high-dose group and the MCFA group (680 mg/kg) showed a longer weight-loaded swimming time (104 ± 29 min, P = 0.087, and 108 ± 11 min, P = 0.047, respectively) and significantly higher hepatic glycogen (16.40 ± 1.45 mg/g, P < 0.001 and 17.27 ± 2.13 mg/g, P < 0.001, respectively) than the control group (59 ± 11 min and 8.79 ± 2.76 mg/g, respectively). Moreover, serum urea nitrogen (891.5 ± 113.4 mg/L, P = 0.024, and 876.6 ± 70.8 mg/L, P = 0.015, respectively) and blood lactic acid (6.05 ± 1.40 mmol/L, P = 0.001, and 5.95 ± 1.27 mmol/L, P < 0.001, respectively) in the high-dose group and the group with an equivalent MCFA dose were significantly lower than those in the control group (1153.6 ± 102.5 mg/L and 12.53 ± 1.86 mmol/L, respectively). Conclusion: Similar to MCFAs, MCFA nanoliposomes prepared by high-pressure microfluidization showed a strong easy energy-supply property, which suggested that MCFA nanoliposomes could be a potential drug candidate for an easy energy supply.",

keywords = "Easy energy supply, High-pressure microfluidization, Medium-chain fatty acids, Nanoliposomes, Stability",

author = "Wei Liu and Liu, {Wei Lin} and Liu, {Cheng Mei} and Liu, {Jian Hua} and Yang, {Shui Bing} and Zheng, {Hui Juan} and Lei, {Han Wu} and Roger Ruan and Ti Li and Tu, {Zong Cai} and Song, {Xin Yong}",

note = "Funding Information: This research was supported by the National High Technology Research and Development Program of China (863 Program, grant 2007AA100403 ), the Key Project of “863” (grant 2008AA10Z330 ), and the Objective-Oriented Project of the State Key Laboratory of Food Science and Technology, Nanchang University (grant SKLF-MB-200808 ). ",

year = "2011",

month = jun,

doi = "10.1016/j.nut.2010.06.010",

language = "English (US)",

volume = "27",

pages = "700--706",

journal = "Nutrition International",

issn = "0888-1294",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Medium-chain fatty acid nanoliposomes for easy energy supply

AU - Liu, Wei

AU - Liu, Wei Lin

AU - Liu, Cheng Mei

AU - Liu, Jian Hua

AU - Yang, Shui Bing

AU - Zheng, Hui Juan

AU - Lei, Han Wu

AU - Ruan, Roger

AU - Li, Ti

AU - Tu, Zong Cai

AU - Song, Xin Yong

N1 - Funding Information: This research was supported by the National High Technology Research and Development Program of China (863 Program, grant 2007AA100403 ), the Key Project of “863” (grant 2008AA10Z330 ), and the Objective-Oriented Project of the State Key Laboratory of Food Science and Technology, Nanchang University (grant SKLF-MB-200808 ).

PY - 2011/6

Y1 - 2011/6

N2 - Objective: Developing a nanoliposome delivery system for an easy energy supply of medium-chain fatty acids (MCFAs) to improve oral doses and bioavailability. Methods: Bangham's method and high-pressure microfluidization were used to prepare MCFA liposomes. The easy energy-supply property of MCFA nanoliposomes was estimated by the anti-fatigue experiments of mice including a weight-loaded swimming test and its corresponding parameters (serum urea nitrogen, blood lactic acid, and hepatic glycogen). For comparison, nanoliposomes without MCFAs and MCFAs not entrapped in nanoliposomes were used throughout. Results: Compared with crude MCFA liposomes according to Bangham's method, the MCFA nanoliposomes made by high-pressure microfluidization exhibited great advantages in their characteristics, with a small average diameter (76.2 ± 34.7 nm), narrow size distribution (polydispersity index 0.207), high ζ-potential (-50.51 mV), great entrapment efficiency (70.5%) and drug loading (9.4%), and good stability. The high-dose group and the MCFA group (680 mg/kg) showed a longer weight-loaded swimming time (104 ± 29 min, P = 0.087, and 108 ± 11 min, P = 0.047, respectively) and significantly higher hepatic glycogen (16.40 ± 1.45 mg/g, P < 0.001 and 17.27 ± 2.13 mg/g, P < 0.001, respectively) than the control group (59 ± 11 min and 8.79 ± 2.76 mg/g, respectively). Moreover, serum urea nitrogen (891.5 ± 113.4 mg/L, P = 0.024, and 876.6 ± 70.8 mg/L, P = 0.015, respectively) and blood lactic acid (6.05 ± 1.40 mmol/L, P = 0.001, and 5.95 ± 1.27 mmol/L, P < 0.001, respectively) in the high-dose group and the group with an equivalent MCFA dose were significantly lower than those in the control group (1153.6 ± 102.5 mg/L and 12.53 ± 1.86 mmol/L, respectively). Conclusion: Similar to MCFAs, MCFA nanoliposomes prepared by high-pressure microfluidization showed a strong easy energy-supply property, which suggested that MCFA nanoliposomes could be a potential drug candidate for an easy energy supply.

AB - Objective: Developing a nanoliposome delivery system for an easy energy supply of medium-chain fatty acids (MCFAs) to improve oral doses and bioavailability. Methods: Bangham's method and high-pressure microfluidization were used to prepare MCFA liposomes. The easy energy-supply property of MCFA nanoliposomes was estimated by the anti-fatigue experiments of mice including a weight-loaded swimming test and its corresponding parameters (serum urea nitrogen, blood lactic acid, and hepatic glycogen). For comparison, nanoliposomes without MCFAs and MCFAs not entrapped in nanoliposomes were used throughout. Results: Compared with crude MCFA liposomes according to Bangham's method, the MCFA nanoliposomes made by high-pressure microfluidization exhibited great advantages in their characteristics, with a small average diameter (76.2 ± 34.7 nm), narrow size distribution (polydispersity index 0.207), high ζ-potential (-50.51 mV), great entrapment efficiency (70.5%) and drug loading (9.4%), and good stability. The high-dose group and the MCFA group (680 mg/kg) showed a longer weight-loaded swimming time (104 ± 29 min, P = 0.087, and 108 ± 11 min, P = 0.047, respectively) and significantly higher hepatic glycogen (16.40 ± 1.45 mg/g, P < 0.001 and 17.27 ± 2.13 mg/g, P < 0.001, respectively) than the control group (59 ± 11 min and 8.79 ± 2.76 mg/g, respectively). Moreover, serum urea nitrogen (891.5 ± 113.4 mg/L, P = 0.024, and 876.6 ± 70.8 mg/L, P = 0.015, respectively) and blood lactic acid (6.05 ± 1.40 mmol/L, P = 0.001, and 5.95 ± 1.27 mmol/L, P < 0.001, respectively) in the high-dose group and the group with an equivalent MCFA dose were significantly lower than those in the control group (1153.6 ± 102.5 mg/L and 12.53 ± 1.86 mmol/L, respectively). Conclusion: Similar to MCFAs, MCFA nanoliposomes prepared by high-pressure microfluidization showed a strong easy energy-supply property, which suggested that MCFA nanoliposomes could be a potential drug candidate for an easy energy supply.

KW - Easy energy supply

KW - High-pressure microfluidization

KW - Medium-chain fatty acids

KW - Nanoliposomes

KW - Stability

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ER -

Medium-chain fatty acid nanoliposomes for easy energy supply

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

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