Medicine: Tau suppression in a neurodegenerative mouse model improves memory function

K. Santacruz, J. Lewis, T. Spires, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McCowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, K. H. Ashe

Research output: Contribution to journalArticle

1229 Citations (Scopus)

Abstract

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.

Original languageEnglish (US)
Pages (from-to)476-481
Number of pages6
JournalScience
Volume309
Issue number5733
DOIs
StatePublished - Jul 15 2005

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Neurofibrillary Tangles
Medicine
Tauopathies
Neurodegenerative Diseases
Neurons
Brain

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Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., ... Ashe, K. H. (2005). Medicine: Tau suppression in a neurodegenerative mouse model improves memory function. Science, 309(5733), 476-481. https://doi.org/10.1126/science.1113694

Medicine : Tau suppression in a neurodegenerative mouse model improves memory function. / Santacruz, K.; Lewis, J.; Spires, T.; Paulson, J.; Kotilinek, L.; Ingelsson, M.; Guimaraes, A.; DeTure, M.; Ramsden, M.; McCowan, E.; Forster, C.; Yue, M.; Orne, J.; Janus, C.; Mariash, A.; Kuskowski, M.; Hyman, B.; Hutton, M.; Ashe, K. H.

In: Science, Vol. 309, No. 5733, 15.07.2005, p. 476-481.

Research output: Contribution to journalArticle

Santacruz, K, Lewis, J, Spires, T, Paulson, J, Kotilinek, L, Ingelsson, M, Guimaraes, A, DeTure, M, Ramsden, M, McCowan, E, Forster, C, Yue, M, Orne, J, Janus, C, Mariash, A, Kuskowski, M, Hyman, B, Hutton, M & Ashe, KH 2005, 'Medicine: Tau suppression in a neurodegenerative mouse model improves memory function', Science, vol. 309, no. 5733, pp. 476-481. https://doi.org/10.1126/science.1113694
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M et al. Medicine: Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005 Jul 15;309(5733):476-481. https://doi.org/10.1126/science.1113694
Santacruz, K. ; Lewis, J. ; Spires, T. ; Paulson, J. ; Kotilinek, L. ; Ingelsson, M. ; Guimaraes, A. ; DeTure, M. ; Ramsden, M. ; McCowan, E. ; Forster, C. ; Yue, M. ; Orne, J. ; Janus, C. ; Mariash, A. ; Kuskowski, M. ; Hyman, B. ; Hutton, M. ; Ashe, K. H. / Medicine : Tau suppression in a neurodegenerative mouse model improves memory function. In: Science. 2005 ; Vol. 309, No. 5733. pp. 476-481.
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