Medical Consequences of Persistent Viral Infection

Jeffrey S. Flier, Lisa H. Underhill, Peter Southern, Michael B.a. Oldstone

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Most of our knowledge about the medical implications of viral disease comes from studies of acute viral infections.1 2 3 As a result of such studies, we now understand the clinical courses and pathogenic mechanisms of acute infections, and attempts to control infection through manipulation of the immune system — i.e., vaccination — have been described. Yet the future of medical virology will probably relate far more to persistent viral infections and the diseases associated with them.4 5 6 Included within this group are many of the herpesviruses (herpes simplex, cytomegalovirus, Epstein–Barr virus, varicella–zoster virus), hepatitis B virus, human T-cell lymphotropic virus (HTLV) Types…

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalNew England Journal of Medicine
Issue number6
StatePublished - Feb 6 1986
Externally publishedYes


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