TY - JOUR
T1 - Medical conditions and risk of adult myeloid leukemia
AU - Johnson, Kimberly J.
AU - Blair, Cindy M.
AU - Fink, James M.
AU - Cerhan, James R.
AU - Roesler, Michelle A.
AU - Hirsch, Betsy A.
AU - Nguyen, Phuong L.
AU - Ross, Julie A.
N1 - Funding Information:
Acknowledgments The authors acknowledged the grants from NIH T32 CA099936, R25 CA047888, R01 CA107143, and K05 CA157439.
PY - 2012/7
Y1 - 2012/7
N2 - Purpose: Although a few previous studies have reported positive associations between adult myeloid leukemia and a history of certain medical conditions, the etiology of most cases remains largely unknown. Our purpose was to examine associations between certain medical conditions and adult myeloid leukemia. Methods: Using logistic regression, we evaluated associations between 16 self-reported medical conditions and myeloid leukemia in a case-control study of 670 cases [including 420 acute myeloid leukemia (AML) and 186 chronic myelogenous leukemia (CML)] and 701 population-based controls. Results: We observed significant positive associations between AML and ulcerative colitis (odds ratio (OR) = 3.8; 95 % confidence interval (CI), 1.1-13) and between CML and peptic ulcer (OR = 2.0; 95% CI, 1.1-3.8). A personal cancer history increased both AML (OR = 2.6; 95% CI, 1.7-3.9) and CML (OR = 3.5; 95% CI, 2.0-5.8) risk even after excluding individuals who reported prior radiation and/or chemotherapy treatment. Conclusion: Certain inflammatory medical conditions and a personal history of cancer, independent from therapy, are associated with an increased risk of myeloid leukemia.
AB - Purpose: Although a few previous studies have reported positive associations between adult myeloid leukemia and a history of certain medical conditions, the etiology of most cases remains largely unknown. Our purpose was to examine associations between certain medical conditions and adult myeloid leukemia. Methods: Using logistic regression, we evaluated associations between 16 self-reported medical conditions and myeloid leukemia in a case-control study of 670 cases [including 420 acute myeloid leukemia (AML) and 186 chronic myelogenous leukemia (CML)] and 701 population-based controls. Results: We observed significant positive associations between AML and ulcerative colitis (odds ratio (OR) = 3.8; 95 % confidence interval (CI), 1.1-13) and between CML and peptic ulcer (OR = 2.0; 95% CI, 1.1-3.8). A personal cancer history increased both AML (OR = 2.6; 95% CI, 1.7-3.9) and CML (OR = 3.5; 95% CI, 2.0-5.8) risk even after excluding individuals who reported prior radiation and/or chemotherapy treatment. Conclusion: Certain inflammatory medical conditions and a personal history of cancer, independent from therapy, are associated with an increased risk of myeloid leukemia.
KW - Acute myeloid leukemia
KW - Autoimmune disorders
KW - Chronic myeloid leukemia
KW - Medical conditions
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U2 - 10.1007/s10552-012-9977-y
DO - 10.1007/s10552-012-9977-y
M3 - Article
C2 - 22576581
AN - SCOPUS:84862489354
SN - 0957-5243
VL - 23
SP - 1083
EP - 1089
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 7
ER -
