Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

R. M. Quock; J. A. Best; D. C. Chen; L. K. Vaughn; P. S. Portoghese; A. E. Takemori

doi:10.1016/0014-2999(90)90158-3

Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

R. M. Quock, J. A. Best, D. C. Chen, L. K. Vaughn, P. S. Portoghese, A. E. Takemori

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

Original language	English (US)
Pages (from-to)	97-100
Number of pages	4
Journal	European Journal of Pharmacology
Volume	175
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(90)90158-3
State	Published - Jan 3 1990

Bibliographical note

Funding Information:
1 This work was supported by U.S. Public Health Service Grants from the National Institute of Dental Research (NIDR) and National Institute on Drug Abuse (NIDA). 6 Present address: Department of Dental Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, U.S.A. Correspondence to: R.M. Quock, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, U.S.A.

Keywords

Analgesia
Narcotic antagonists
Nitrous oxide
Opioid receptors

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10.1016/0014-2999(90)90158-3

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title = "Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors",

abstract = "Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.",

keywords = "Analgesia, Narcotic antagonists, Nitrous oxide, Opioid receptors",

author = "Quock, {R. M.} and Best, {J. A.} and Chen, {D. C.} and Vaughn, {L. K.} and Portoghese, {P. S.} and Takemori, {A. E.}",

note = "Funding Information: 1 This work was supported by U.S. Public Health Service Grants from the National Institute of Dental Research (NIDR) and National Institute on Drug Abuse (NIDA). 6 Present address: Department of Dental Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, U.S.A. Correspondence to: R.M. Quock, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, U.S.A.",

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T1 - Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

AU - Quock, R. M.

AU - Best, J. A.

AU - Chen, D. C.

AU - Vaughn, L. K.

AU - Portoghese, P. S.

AU - Takemori, A. E.

N1 - Funding Information: 1 This work was supported by U.S. Public Health Service Grants from the National Institute of Dental Research (NIDR) and National Institute on Drug Abuse (NIDA). 6 Present address: Department of Dental Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, U.S.A. Correspondence to: R.M. Quock, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, U.S.A.

PY - 1990/1/3

Y1 - 1990/1/3

N2 - Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

AB - Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

KW - Analgesia

KW - Narcotic antagonists

KW - Nitrous oxide

KW - Opioid receptors

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Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

Abstract

Bibliographical note

Keywords

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