Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

R. M. Quock, J. A. Best, D. C. Chen, L. K. Vaughn, P. S. Portoghese, A. E. Takemori

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Jan 3 1990

Bibliographical note

Funding Information:
1 This work was supported by U.S. Public Health Service Grants from the National Institute of Dental Research (NIDR) and National Institute on Drug Abuse (NIDA). 6 Present address: Department of Dental Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, U.S.A. Correspondence to: R.M. Quock, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, U.S.A.


  • Analgesia
  • Narcotic antagonists
  • Nitrous oxide
  • Opioid receptors


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