Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.
Bibliographical noteFunding Information:
1 This work was supported by U.S. Public Health Service Grants from the National Institute of Dental Research (NIDR) and National Institute on Drug Abuse (NIDA). 6 Present address: Department of Dental Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, U.S.A. Correspondence to: R.M. Quock, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, U.S.A.
- Narcotic antagonists
- Nitrous oxide
- Opioid receptors