Mechanistic insights into maternal–fetal cross talk and islet beta-cell development

Research output: Contribution to journalReview articlepeer-review


The metabolic health trajectory of an individual is shaped as early as prepregnancy, during pregnancy, and lactation period. Both maternal nutrition and metabolic health status are critical factors in the programming of offspring toward an increased propensity to developing type 2 diabetes in adulthood. Pancreatic beta-cells, part of the endocrine islets, which are nutrient-sensitive tissues important for glucose metabolism, are primed early in life (the first 1000 days in humans) with limited plasticity later in life. This suggests the high importance of the developmental window of programming in utero and early in life.

Original languageEnglish (US)
Article number259:3 e230069
JournalJournal of Endocrinology
Issue number3
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 BioScientifica Ltd.. All rights reserved.


  • diabetes
  • islet cells
  • pancreas
  • placenta
  • pregnancy
  • Maternal Nutritional Physiological Phenomena
  • Lactation
  • Humans
  • Insulin-Secreting Cells/metabolism
  • Diabetes Mellitus, Type 2/etiology
  • Pregnancy
  • Placenta
  • Female

PubMed: MeSH publication types

  • Review
  • Journal Article
  • Research Support, N.I.H., Extramural


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