Abstract
The metabolic health trajectory of an individual is shaped as early as prepregnancy, during pregnancy, and lactation period. Both maternal nutrition and metabolic health status are critical factors in the programming of offspring toward an increased propensity to developing type 2 diabetes in adulthood. Pancreatic beta-cells, part of the endocrine islets, which are nutrient-sensitive tissues important for glucose metabolism, are primed early in life (the first 1000 days in humans) with limited plasticity later in life. This suggests the high importance of the developmental window of programming in utero and early in life.
Original language | English (US) |
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Article number | 259:3 e230069 |
Journal | Journal of Endocrinology |
Volume | 259 |
Issue number | 3 |
DOIs | |
State | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 BioScientifica Ltd.. All rights reserved.
Keywords
- diabetes
- islet cells
- pancreas
- placenta
- pregnancy
- Maternal Nutritional Physiological Phenomena
- Lactation
- Humans
- Insulin-Secreting Cells/metabolism
- Diabetes Mellitus, Type 2/etiology
- Pregnancy
- Placenta
- Female
PubMed: MeSH publication types
- Review
- Journal Article
- Research Support, N.I.H., Extramural