Iron is an essential element for nearly all life on Earth, primarily for its value as a redox active cofactor. Iron exists predominantly in two biologically relevant redox states: ferric iron, the oxidized state (Fe3+), and ferrous iron, the reduced state (Fe2+). Fe2+ is well known to facilitate electron transfer reactions that can lead to the generation of reactive oxygen species. Less is known about why iron is toxic to cells in the absence of oxygen, yet this phenomenon is critically important for our understanding of life on early Earth and in iron-rich ecosystems today. In this brief review, we will highlight our current understanding of anaerobic Fe2+ toxicity, focusing on molecular mechanistic studies in several model systems.
|Original language||English (US)|
|Number of pages||5|
|Journal||Free Radical Biology and Medicine|
|State||Published - Aug 20 2019|
Bibliographical noteFunding Information:
This work was supported by a grant from the Office of Naval Research ( N000141310552 ) to JAG. We thank Lina Bird and the anonymous reviewers for helpful comments on the manuscript.
© 2019 Elsevier Inc.