Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism

Kai Chien Yang, John W. Kyle, Jonathan C. Makielski, Samuel C. Dudley

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.

Original languageEnglish (US)
Pages (from-to)1937-1955
Number of pages19
JournalCirculation research
Issue number12
StatePublished - Jun 5 2015

Bibliographical note

Publisher Copyright:
© 2015 American Heart Association, Inc.


  • cardiac arrhythmias
  • death, sudden, cardiac
  • metabolism
  • oxidative stress


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