Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

There are three major mechanisms of resistance of Staphylococcus aureus to beta-lactam antibiotics: enzyme mediated (penicillinase or beta-lactamase) by which the antibiotic is inactivated; intrinsic, which is not due to drug inactivation, and accounts for methicillin-resistance; and tolerance, in which there is a dissociation of the inhibitory and killing actions of beta-lactam antibiotics. In enzyme-mediated resistance, there are at least three different staphylococcal beta-lactamases, which probably account for differences in the inoculum effect with different cephalosporins. The intrinsic resistance is associated with differences in the affinity of beta-lactams for penicillin-binding proteins, but intrinsic resistance is probably more complex, because the pH of the medium, chelating agents, visible light, and temperature also effect its expression. Tolerance is clearly due to decreased autolytic enzyme activity (reflecting persistence of an enzyme inhibitor) of those tolerant organisms that need 32 (or more) times as much antibiotic for a bactericidal effect as for simple inhibition.
Original languageUndefined/Unknown
Pages (from-to)339-344
Number of pages6
JournalAnnals of Internal Medicine
Volume97
Issue number3
StatePublished - 1982

Keywords

  • Anti-Bacterial Agents/pd [Pharmacology]
  • Anti-Bacterial Agents/tu [Therapeutic Use]
  • Cephalosporins/pd [Pharmacology]
  • Drug Tolerance
  • Microbial Sensitivity Tests
  • Penicillin Resistance
  • Penicillinase/me [Metabolism]
  • Penicillins/pd [Pharmacology]
  • Staphylococcal Infections/dt [Drug Therapy]
  • Staphylococcus aureus/de [Drug Effects]
  • beta-Lactamases/me [Metabolism]

Cite this

Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus. / Sabath, L. D.

In: Annals of Internal Medicine, Vol. 97, No. 3, 1982, p. 339-344.

Research output: Contribution to journalArticle

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title = "Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus.",
abstract = "There are three major mechanisms of resistance of Staphylococcus aureus to beta-lactam antibiotics: enzyme mediated (penicillinase or beta-lactamase) by which the antibiotic is inactivated; intrinsic, which is not due to drug inactivation, and accounts for methicillin-resistance; and tolerance, in which there is a dissociation of the inhibitory and killing actions of beta-lactam antibiotics. In enzyme-mediated resistance, there are at least three different staphylococcal beta-lactamases, which probably account for differences in the inoculum effect with different cephalosporins. The intrinsic resistance is associated with differences in the affinity of beta-lactams for penicillin-binding proteins, but intrinsic resistance is probably more complex, because the pH of the medium, chelating agents, visible light, and temperature also effect its expression. Tolerance is clearly due to decreased autolytic enzyme activity (reflecting persistence of an enzyme inhibitor) of those tolerant organisms that need 32 (or more) times as much antibiotic for a bactericidal effect as for simple inhibition.",
keywords = "Anti-Bacterial Agents/pd [Pharmacology], Anti-Bacterial Agents/tu [Therapeutic Use], Cephalosporins/pd [Pharmacology], Drug Tolerance, Microbial Sensitivity Tests, Penicillin Resistance, Penicillinase/me [Metabolism], Penicillins/pd [Pharmacology], Staphylococcal Infections/dt [Drug Therapy], Staphylococcus aureus/de [Drug Effects], beta-Lactamases/me [Metabolism]",
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TY - JOUR

T1 - Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus.

AU - Sabath, L. D.

PY - 1982

Y1 - 1982

N2 - There are three major mechanisms of resistance of Staphylococcus aureus to beta-lactam antibiotics: enzyme mediated (penicillinase or beta-lactamase) by which the antibiotic is inactivated; intrinsic, which is not due to drug inactivation, and accounts for methicillin-resistance; and tolerance, in which there is a dissociation of the inhibitory and killing actions of beta-lactam antibiotics. In enzyme-mediated resistance, there are at least three different staphylococcal beta-lactamases, which probably account for differences in the inoculum effect with different cephalosporins. The intrinsic resistance is associated with differences in the affinity of beta-lactams for penicillin-binding proteins, but intrinsic resistance is probably more complex, because the pH of the medium, chelating agents, visible light, and temperature also effect its expression. Tolerance is clearly due to decreased autolytic enzyme activity (reflecting persistence of an enzyme inhibitor) of those tolerant organisms that need 32 (or more) times as much antibiotic for a bactericidal effect as for simple inhibition.

AB - There are three major mechanisms of resistance of Staphylococcus aureus to beta-lactam antibiotics: enzyme mediated (penicillinase or beta-lactamase) by which the antibiotic is inactivated; intrinsic, which is not due to drug inactivation, and accounts for methicillin-resistance; and tolerance, in which there is a dissociation of the inhibitory and killing actions of beta-lactam antibiotics. In enzyme-mediated resistance, there are at least three different staphylococcal beta-lactamases, which probably account for differences in the inoculum effect with different cephalosporins. The intrinsic resistance is associated with differences in the affinity of beta-lactams for penicillin-binding proteins, but intrinsic resistance is probably more complex, because the pH of the medium, chelating agents, visible light, and temperature also effect its expression. Tolerance is clearly due to decreased autolytic enzyme activity (reflecting persistence of an enzyme inhibitor) of those tolerant organisms that need 32 (or more) times as much antibiotic for a bactericidal effect as for simple inhibition.

KW - Anti-Bacterial Agents/pd [Pharmacology]

KW - Anti-Bacterial Agents/tu [Therapeutic Use]

KW - Cephalosporins/pd [Pharmacology]

KW - Drug Tolerance

KW - Microbial Sensitivity Tests

KW - Penicillin Resistance

KW - Penicillinase/me [Metabolism]

KW - Penicillins/pd [Pharmacology]

KW - Staphylococcal Infections/dt [Drug Therapy]

KW - Staphylococcus aureus/de [Drug Effects]

KW - beta-Lactamases/me [Metabolism]

M3 - Article

VL - 97

SP - 339

EP - 344

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

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ER -