Abstract
Post-transcriptional control plays a pervasive role in the regulation of gene expression, with direct relevance to the proper function of endocrine systems. This chapter explores the mechanisms that control protein expression at the levels of translation and mRNA degradation. First, we provide an overview of the pathways and factors involved in these processes. Next, we discuss the cis and trans-acting factors that modulate the amount, timing, and location of protein production and that regulate the rates of mRNA degradation. To emphasize key concepts in post-transcriptional control, we present prime examples of signals and regulatory factors that control mRNAs. Among these, we explore RNA binding proteins and non-coding RNAs that specifically and potently influence mRNA fate.
| Original language | English (US) |
|---|---|
| Title of host publication | Post-Transcriptional Mechanisms in Endocrine Regulation |
| Publisher | Springer International Publishing |
| Pages | 1-36 |
| Number of pages | 36 |
| ISBN (Electronic) | 9783319251240 |
| ISBN (Print) | 9783319251226 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© Springer International Publishing Switzerland 2016.
Keywords
- Competing endogenous RNAs (ceRNAs)
- Cytoplasmic poly-adenylation element binding protein (CPEB)
- Deadenylation
- Decapping
- Endoribonuclease
- Exoribonuclease
- Gene regulation
- Internal ribosome entry site (IRES)
- MiRNA sponges
- MicroRNA
- Nanos
- Non-coding RNA
- Poly-adenosine binding protein (PABP)
- Pumilio and Fem-3 binding factor proteins (PUFs)
- RNA binding proteins
- RNA decay
- RNA induced silencing complex (RISC)
- RNA localization
- RNA processing
- Translation initiation and elongation
- Translational control
- Untranslated regions (UTRs)
- eIF4E binding protein (4EBP)