Mechanisms of post-transcriptional gene regulation

René Arvola, Elizabeth Abshire, Jennifer Bohn, Aaron Goldstrohm

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Post-transcriptional control plays a pervasive role in the regulation of gene expression, with direct relevance to the proper function of endocrine systems. This chapter explores the mechanisms that control protein expression at the levels of translation and mRNA degradation. First, we provide an overview of the pathways and factors involved in these processes. Next, we discuss the cis and trans-acting factors that modulate the amount, timing, and location of protein production and that regulate the rates of mRNA degradation. To emphasize key concepts in post-transcriptional control, we present prime examples of signals and regulatory factors that control mRNAs. Among these, we explore RNA binding proteins and non-coding RNAs that specifically and potently influence mRNA fate.

Original languageEnglish (US)
Title of host publicationPost-Transcriptional Mechanisms in Endocrine Regulation
PublisherSpringer International Publishing
Pages1-36
Number of pages36
ISBN (Electronic)9783319251240
ISBN (Print)9783319251226
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Competing endogenous RNAs (ceRNAs)
  • Cytoplasmic poly-adenylation element binding protein (CPEB)
  • Deadenylation
  • Decapping
  • Endoribonuclease
  • Exoribonuclease
  • Gene regulation
  • Internal ribosome entry site (IRES)
  • MiRNA sponges
  • MicroRNA
  • Nanos
  • Non-coding RNA
  • Poly-adenosine binding protein (PABP)
  • Pumilio and Fem-3 binding factor proteins (PUFs)
  • RNA binding proteins
  • RNA decay
  • RNA induced silencing complex (RISC)
  • RNA localization
  • RNA processing
  • Translation initiation and elongation
  • Translational control
  • Untranslated regions (UTRs)
  • eIF4E binding protein (4EBP)

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