Mechanisms of muscle dedifferentiation during regeneration

Karen Echeverri, Elly M. Tanaka

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


For many years people have known that amphibians have an amazing ability to regenerate lost body parts. In contrast humans have limited regeneration capacity and even simple wound healing results in scarring. Despite more than a century of scientific inquiry, this remarkable phenomenon remains poorly understood. Recent research has begun to provide insight into how this unique process that is now fully accepted to occur via the reversal of cell differentiation is executed at the molecular level. As more and more is known about regeneration and dedifferentiation we can begin to address the question: if given the right signals could mammals also regenerate body structures?

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalSeminars in Cell and Developmental Biology
Issue number5
StatePublished - 2002


  • Amphibians
  • Blastema
  • Dedifferentiation
  • Myotubes


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