Mechanisms of memory loss in Aβ and tau mouse models

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Abstract

Although memory loss is the central symptom of Alzheimer's disease, the pathophysiological mechanisms leading to dementia are poorly understood. It is difficult to answer this issue with studies in humans and impossible in cultured cells. Therefore animal models are needed to elucidate the molecular mechanisms leading to dementia. The chief neuropathological changes during Alzheimer's disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to focus upon in the animal models, specifically Aβ (amyloid β) and tau. This paper presents my perspective on what we have learnt about mechanisms of memory loss from Aβ and tau mouse models of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalBiochemical Society transactions
Volume33
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • APP transgenic mice
  • Alzheimer's disease
  • Amyloid plaque
  • Memory loss
  • Tau

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