Mechanisms of memory loss in Aβ and tau mouse models

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Although memory loss is the central symptom of Alzheimer's disease, the pathophysiological mechanisms leading to dementia are poorly understood. It is difficult to answer this issue with studies in humans and impossible in cultured cells. Therefore animal models are needed to elucidate the molecular mechanisms leading to dementia. The chief neuropathological changes during Alzheimer's disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to focus upon in the animal models, specifically Aβ (amyloid β) and tau. This paper presents my perspective on what we have learnt about mechanisms of memory loss from Aβ and tau mouse models of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalBiochemical Society transactions
Volume33
Issue number4
DOIs
StatePublished - Aug 1 2005

Fingerprint

Memory Disorders
Alzheimer Disease
Amyloid
Data storage equipment
Dementia
Animals
Animal Models
Neurofibrillary Tangles
Amyloid Plaques
Cultured Cells
Cells
Molecules

Keywords

  • APP transgenic mice
  • Alzheimer's disease
  • Amyloid plaque
  • Memory loss
  • Tau

Cite this

Mechanisms of memory loss in Aβ and tau mouse models. / Ashe, Karen H.

In: Biochemical Society transactions, Vol. 33, No. 4, 01.08.2005, p. 591-594.

Research output: Contribution to journalArticle

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