Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components

John E Foker; D. Scott Clark; Richard J. Pickering; Robert A. Good; Richard L. Varco

Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components

John E Foker, D. Scott Clark, Richard J. Pickering, Robert A. Good, Richard L. Varco

Surgery

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Abstract

We have produced evidence using a dog kidney allograft model that in graft rejection at least two mechanisms are responsible for leukocytic infiltration. Both are circulating under the conditions of this model. The first induces perivascular infiltration by round cells, does not seem to be complement dependent, and may be a prior condition for this infiltration. The second activates the complement system attracting neutrophils. The production of both factors is underway after 24 hours of sensitization.

Original language	English (US)
Pages (from-to)	42-50
Number of pages	9
Journal	Surgery
Volume	66
Issue number	1
State	Published - Jul 1 1969

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title = "Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components",

abstract = "We have produced evidence using a dog kidney allograft model that in graft rejection at least two mechanisms are responsible for leukocytic infiltration. Both are circulating under the conditions of this model. The first induces perivascular infiltration by round cells, does not seem to be complement dependent, and may be a prior condition for this infiltration. The second activates the complement system attracting neutrophils. The production of both factors is underway after 24 hours of sensitization.",

author = "Foker, {John E} and Clark, {D. Scott} and Pickering, {Richard J.} and Good, {Robert A.} and Varco, {Richard L.}",

year = "1969",

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T1 - Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components

AU - Foker, John E

AU - Clark, D. Scott

AU - Pickering, Richard J.

AU - Good, Robert A.

AU - Varco, Richard L.

PY - 1969/7/1

Y1 - 1969/7/1

N2 - We have produced evidence using a dog kidney allograft model that in graft rejection at least two mechanisms are responsible for leukocytic infiltration. Both are circulating under the conditions of this model. The first induces perivascular infiltration by round cells, does not seem to be complement dependent, and may be a prior condition for this infiltration. The second activates the complement system attracting neutrophils. The production of both factors is underway after 24 hours of sensitization.

AB - We have produced evidence using a dog kidney allograft model that in graft rejection at least two mechanisms are responsible for leukocytic infiltration. Both are circulating under the conditions of this model. The first induces perivascular infiltration by round cells, does not seem to be complement dependent, and may be a prior condition for this infiltration. The second activates the complement system attracting neutrophils. The production of both factors is underway after 24 hours of sensitization.

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M3 - Article

C2 - 4892312

AN - SCOPUS:0014548424

SN - 0039-6060

VL - 66

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JO - Surgery

JF - Surgery

IS - 1

ER -

Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components

Abstract

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