Mechanisms of Intrinsic Tumor Resistance to Immunotherapy

John Rieth, Subree Subramanian

Research output: Contribution to journalReview article

Abstract

An increased understanding of the interactions between the immune system and tumors has opened the door to immunotherapy for cancer patients. Despite some success with checkpoint inhibitors including ipilimumab, pembrolizumab, and nivolumab, most cancer patients remain unresponsive to such immunotherapy, likely due to intrinsic tumor resistance. The mechanisms most likely involve reducing the quantity and/or quality of antitumor lymphocytes, which ultimately are driven by any number of developments: tumor mutations and adaptations, reduced neoantigen generation or expression, indoleamine 2,3-dioxygenase (IDO) overexpression, loss of phosphatase and tensin homologue (PTEN) expression, and overexpression of the Wnt⁻β-catenin pathway. Current work in immunotherapy continues to identify various tumor resistance mechanisms; future work is needed to develop adjuvant treatments that target those mechanisms, in order to improve the efficacy of immunotherapy and to expand its scope.

Original languageEnglish (US)
JournalInternational journal of molecular sciences
Volume19
Issue number5
DOIs
StatePublished - May 2 2018

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Immunotherapy
Tumors
tumors
Neoplasms
cancer
Indoleamine-Pyrrole 2,3,-Dioxygenase
immune systems
Catenins
phosphatases
Lymphocytes
Immune system
lymphocytes
Phosphatases
mutations
Phosphoric Monoester Hydrolases
inhibitors
Immune System
Mutation
interactions

Keywords

  • cancer immunotherapy
  • oncogenes
  • resistance
  • signaling pathways

Cite this

Mechanisms of Intrinsic Tumor Resistance to Immunotherapy. / Rieth, John; Subramanian, Subree.

In: International journal of molecular sciences, Vol. 19, No. 5, 02.05.2018.

Research output: Contribution to journalReview article

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