Mechanisms of disease: Psoriasis

Frank O. Nestle, Daniel H. Kaplan, Jonathan Barker

Research output: Contribution to journalArticlepeer-review

2413 Scopus citations


This review emphasizes the pathologic features of psoriatic lesions, recent genetic studies of psoriasis, and immunologic factors in the disease. The evolution of a psoriatic lesion entails a complex interplay between environmental and genetic factors, which sets the scene for a cascade of events that activate dendritic cells and T cells. Cross-talk between epithelial cells and immune cells shapes and maintains the inflammatory milieu.

Original languageEnglish (US)
Pages (from-to)496-509+444
JournalNew England Journal of Medicine
Issue number5
StatePublished - Jul 30 2009
Externally publishedYes

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