Mechanisms of disease: Psoriasis

Frank O. Nestle; Daniel H. Kaplan; Jonathan Barker

doi:10.1056/NEJMra0804595

Mechanisms of disease: Psoriasis

Frank O. Nestle, Daniel H. Kaplan, Jonathan Barker

Dermatology

Research output: Contribution to journal › Article › peer-review

2174 Scopus citations

Abstract

This review emphasizes the pathologic features of psoriatic lesions, recent genetic studies of psoriasis, and immunologic factors in the disease. The evolution of a psoriatic lesion entails a complex interplay between environmental and genetic factors, which sets the scene for a cascade of events that activate dendritic cells and T cells. Cross-talk between epithelial cells and immune cells shapes and maintains the inflammatory milieu.

Original language	English (US)
Pages (from-to)	496-509+444
Journal	New England Journal of Medicine
Volume	361
Issue number	5
DOIs	https://doi.org/10.1056/NEJMra0804595
State	Published - Jul 30 2009

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abstract = "This review emphasizes the pathologic features of psoriatic lesions, recent genetic studies of psoriasis, and immunologic factors in the disease. The evolution of a psoriatic lesion entails a complex interplay between environmental and genetic factors, which sets the scene for a cascade of events that activate dendritic cells and T cells. Cross-talk between epithelial cells and immune cells shapes and maintains the inflammatory milieu.",

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Mechanisms of disease: Psoriasis

Abstract

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