Mechanisms of cancer pain

Brian L. Schmidt, Darryl T. Hamamoto, Donald A. Simone, George L. Wilcox

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations

Abstract

Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.

Original languageEnglish (US)
Pages (from-to)164-178
Number of pages15
JournalMolecular interventions
Volume10
Issue number3
DOIs
StatePublished - Jun 2010

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