Mechanisms of cancer pain

Brian L. Schmidt, Darryl T. Hamamoto, Donald A Simone, George L Wilcox

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.

Original languageEnglish (US)
Pages (from-to)164-178
Number of pages15
JournalMolecular interventions
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2010

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Central Nervous System Sensitization
Neoplasms
Nociceptors
Pain Perception
Animal Models
Research Personnel
Neoplasm Metastasis
Neurons
Pain
Cancer Pain

Cite this

Mechanisms of cancer pain. / Schmidt, Brian L.; Hamamoto, Darryl T.; Simone, Donald A; Wilcox, George L.

In: Molecular interventions, Vol. 10, No. 3, 01.06.2010, p. 164-178.

Research output: Contribution to journalReview article

Schmidt, Brian L. ; Hamamoto, Darryl T. ; Simone, Donald A ; Wilcox, George L. / Mechanisms of cancer pain. In: Molecular interventions. 2010 ; Vol. 10, No. 3. pp. 164-178.
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