Mechanisms maintaining peripheral tolerance

Research output: Contribution to journalReview articlepeer-review

335 Scopus citations


The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalNature immunology
Issue number1
StatePublished - Jan 2010

Bibliographical note

Funding Information:
Supported by the US National Institutes of Health (P01 AI35296 and R01 AI080764).

Copyright 2010 Elsevier B.V., All rights reserved.


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