Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis

Michael W. Klymkowsky, Christy Cortez Rossi, Kristin Bruk Artinger

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


The neural crest is an evolutionary adaptation, with roots in the formation of mesoderm. Modification of neural crest behavior has been critical for the evolutionary diversification of the vertebrates and defects in neural crest underlie a range of human birth defects. There has been a tremendous increase in our knowledge of the molecular, cellular and inductive interactions that converge on defining the neural crest and determining its behavior. While there is a temptation to look for simple models to explain neural crest behavior, the reality is that the system is complex in its circuitry. In this review, our goal is to identify the broad features of neural crest origins (developmentally) and migration (cellularly) using data from the zebrafish (teleost) and Xenopus laevis (tetrapod amphibian) in order to illuminate where general mechanisms appear to be in play and, equally importantly, where disparities in experimental results suggest areas of profitable study.

Original languageEnglish (US)
Pages (from-to)595-608
Number of pages14
JournalCell Adhesion and Migration
Issue number4
StatePublished - 2010
Externally publishedYes


  • Evolution
  • Induction
  • Mesoderm
  • Migration
  • Neural crest


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