Mechanisms by which high maternal fat intake during pregnancy increases breast cancer risk in female rodent offspring

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Emerging evidence indicates that a high in utero estrogenic environment increases breast cancer risk in women. We have proposed that a maternal intake of a high-fat diet is a source for high pregnancy estrogen levels and increases breast cancer risk among female offspring. In this review, the role of dietary fat in breast cancer, particularly during fetal Life, is discussed. In addition, we provide possible mechanisms of action of the effects of a high-fat diet on the breast. These mechanisms include protein kinase C, estrogens and estrogen receptor, and alterations in mammary parenchymal structures.

Original languageEnglish (US)
Pages (from-to)199-214
Number of pages16
JournalBreast Cancer Research and Treatment
Volume46
Issue number2-3
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Breast cancer risk
  • Diet
  • Estrogen receptor
  • Fat
  • Mammary parenchymal structures
  • Maternal nutrition
  • Protein kinase C

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