Mechanisms behind estrogen's beneficial effect on muscle strength in females

Dawn A. Lowe, Kristen A. Baltgalvis, Sarah M. Greising

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


Muscle weakness ensues when serum testosterone declines with age in men. Testosterone's female counterpart, estrogen, also has been implicated in age-related strength loss, but these results are less conclusive. Our working hypothesis is that estrogens do benefit muscle strength, and that the underlying mechanism involves estrogen receptors to improve muscle quality more so than quantity.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalExercise and sport sciences reviews
Issue number2
StatePublished - Apr 2010


  • 17A-estradiol
  • Aging
  • Estrogen receptor
  • Hormone replacement therapy
  • Myosin
  • Skeletal muscle


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