Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling

Timothy R. Rose, Kevin Wickman

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

γ-Aminobutyric acid B receptors (GABABRs) are broadly expressed throughout the central nervous system where they play an important role in regulating neuronal excitability and synaptic transmission. GABABRs are G protein-coupled receptors that mediate slow and sustained inhibitory actions via modulation of several downstream effector enzymes and ion channels. GABABRs are obligate heterodimers that associate with diverse arrays of proteins to form modular complexes that carry out distinct physiological functions. GABABR-dependent signaling is fine-tuned and regulated through a multitude of mechanisms that are relevant to physiological and pathophysiological states. This review summarizes the current knowledge on GABABR signal transduction and discusses key factors that influence the strength and sensitivity of GABABR-dependent signaling in neurons.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Behavioral Neurosciences
PublisherSpringer Science and Business Media Deutschland GmbH
Pages39-79
Number of pages41
Volume52
DOIs
StatePublished - 2022

Publication series

NameCurrent Topics in Behavioral Neurosciences
Volume52
ISSN (Print)1866-3370
ISSN (Electronic)1866-3389

Bibliographical note

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.

Keywords

  • Adenylyl cyclase
  • GABA
  • GABA receptor
  • GIRK channel
  • Phosphorylation
  • Plasticity
  • RGS
  • Voltage-gated Ca channel
  • gamma-Aminobutyric Acid
  • Signal Transduction
  • Neurons
  • Receptors, GABA-B
  • Receptors, GABA

PubMed: MeSH publication types

  • Review
  • Journal Article

Fingerprint

Dive into the research topics of 'Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling'. Together they form a unique fingerprint.

Cite this