Mechanisms and management of bone cancer pain

Patrick W. O'Donnell, Denis R. Clohisy

Research output: Chapter in Book/Report/Conference proceedingChapter


Bone cancer pain is a multifactorial process with many potential targets for therapeutic intervention. As pain is the most common presenting symptom in patients with skeletal metastases and is directly proportional to the patient's quality of life, clinical improvements in the treatment of bone cancer pain are of the utmost importance. Research targeting pain-related cytokines, anti-osteoclastic medications, and ion channels have shown significant clinical progress in the treatment of cancer-related bone pain. With continued efforts into these and other therapeutic strategies, we hope to continue to improve the quality of life of those patients suffering with bone cancer pain.

Original languageEnglish (US)
Title of host publicationBone Cancer
Subtitle of host publicationPrimary Bone Cancers and Bone Metastases: Second Edition
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780124167285
ISBN (Print)9780124167216
StatePublished - Jan 1 2015



  • Bone cancer
  • Pain
  • Skeletal mestastasis

Cite this

O'Donnell, P. W., & Clohisy, D. R. (2015). Mechanisms and management of bone cancer pain. In Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition (pp. 571-577). Elsevier Inc..