Mechanism of RNA 2′-O-Methylation: Evidence that the Catalytic Lysine Acts to Steer Rather than Deprotonate the Target Nucleophile

Keyphrases

• Nucleophile 100%
• Hydroxyl 100%
• 2′-O-methylation 100%
• Catalytic Lysine 100%
• Nucleic Acids 50%
• Methyl 50%
• Methyl Groups 50%
• Polymerase 50%
• Ribozyme 50%
• Deprotonation 50%
• SN2 Pathway 50%
• Oxyanions 50%
• Vaccinia Virus 50%
• VP39 50%
• AdoMet 50%
• 2′-O-MTase 50%

Biochemistry, Genetics and Molecular Biology

• RNA 100%
• O-Methylation 100%
• Lysine 100%
• Enzyme 25%
• Vaccinia Virus 25%
• Deprotonation 25%
• Ribozyme 25%
• RNA Polymerase 25%
• S-Adenosyl Methionine 25%
• Messenger RNA 25%