Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose

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Abstract

A single lot of MCC powder (Avicel PH102) was equilibrated at 0%, 11.35%, 21.6%, 38.2%, 52%, 57.5%, 75% and 84.3% relative humidity. Each equilibrated powder was compressed. Tablet density and tensile strength were measured as a function of pressure. Powder true density, tabletability, compressibility, compactibility and plasticity were obtained as a function of water content. The true density of MCC ranged 1.42-1.46 g/cm3 and exhibited a maximum between ∼3% and ∼5% (wt%) moisture. Moisture up to ∼3.3%, corresponding to monolayer coverage, did not induce profound change in MCC plasticity nor bonding strength despite reduced Tg. Consequently, the compaction properties were largely insensitive to moisture variation below 3.3% water. Above 3.3% water, higher moisture content corresponded to improved plasticity, due to the plasticizing effects of water above the critical water content, and consequently larger interparticulate bonding area when compressed. Effects of plasticization by water on bonding area were significant at low compaction pressures but diminish at higher pressures. At above 3.3% water, increasing moisture content also reduced bonding strength. Due to the interplay among the plasticity, compaction pressure and bonding strength, tablet tensile strength peaked in the range of 3.3-5.6% moisture.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalInternational journal of pharmaceutics
Volume346
Issue number1-2
DOIs
StatePublished - Jan 4 2008

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Antiplasticization
  • Compactibility
  • Compaction
  • Compressibility
  • Microcrystalline cellulose
  • Moisture
  • Plasticity
  • Tabletability

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