Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents

Keyphrases

• Acyl 100%
• Adenylates 100%
• α-keto Acids 100%
• Antibacterial Activity 100%
• Novel Antimicrobials 100%
• Negatively Charged 66%
• Lactol 66%
• Escherichia Coli 33%
• Mechanism of Action 33%
• Site-directed mutagenesis 33%
• Carboxylate 33%
• Menaquinone Biosynthesis 33%
• Arginine 33%
• IC50 Value 33%
• IC50 33%
• X-ray Crystallography 33%
• Side Chain 33%
• Ligation 33%
• Synthetase 33%
• Enzyme Inhibition 33%
• Tight-binding Inhibitors 33%
• Biosynthesis Pathway 33%
• Structure-activity Relationship Studies 33%
• Isomeric Forms 33%
• Open Chain 33%
• Charged Analogue 33%
• Menaquinone 33%
• Promising Target 33%
• Enzyme-catalyzed 33%
• Staphylococcus 33%

Chemistry

• Antibacterial Agent 100%
• Accelerator Mass Spectrometry 100%
• Keto Acids 60%
• Antibacterial 60%
• Menaquinone 40%
• IC50 40%
• Lactol 40%
• Catalysis 20%
• X-Ray Crystallography 20%
• Structure-Activity Relationship 20%
• Biosynthesis 20%
• Carboxylic Acid 20%
• Arginine 20%
• Site-Directed Mutagenesis 20%
• Enzyme Inhibition 20%

Biochemistry, Genetics and Molecular Biology

• Antibacterial Activity 100%
• Adenosine Monophosphate 100%
• IC50 66%
• Anabolism 33%
• Enzyme Catalysis 33%
• X-Ray Crystallography 33%
• Enzyme Inhibition 33%
• Escherichia coli 33%
• Site-Directed Mutagenesis 33%
• Structure Activity Relation 33%
• Staphylococcus Aureus 33%
• Arginine 33%