Mechanism of inhibition of HIV-1 reverse transcriptase by the novel broad-range DNA polymerase inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2- thienyl)acetamide

Keyphrases

• HIV-1 Reverse Transcriptase 100%
• Ethyl 100%
• Reverse Transcriptase 100%
• Inhibition Mechanism 100%
• Phenyl 100%
• Thienyl 100%
• Acetamide 100%
• DNA Polymerase Inhibitors 100%
• DNA Polymerase Activity 50%
• HIV Patients 16%
• AIDS/HIV 16%
• Human Immunodeficiency Virus Type 1 (HIV-1) 16%
• RNase H Activity 16%
• Kinetic Analysis 16%
• Novel Inhibitors 16%
• Non-competitive 16%
• IC50 Value 16%
• DNA Polymerase 16%
• RNA-dependent 16%
• Polymerization Activity 16%
• Effective Compounds 16%
• Reaction Mixture 16%
• RNA-DNA 16%
• Polymerase Activity 16%
• HIV-2 16%
• Gel Shift 16%
• Drug-resistant HIV 16%
• Surface Plasmon Resonance Analysis 16%
• Reverse Transcriptase Inhibition 16%
• Linear Types 16%
• RTDNA 16%
• High-fidelity DNA Polymerase 16%
• Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) 16%
• Anti-HIV Drugs 16%
• Mixed Linear 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Acetamide 100%
• RNA Directed DNA Polymerase 100%
• DNA Polymerase 100%
• HIV 30%
• Anti-Human Immunodeficiency Virus 10%
• Surface Plasmon Resonance 10%
• Ribonuclease 10%
• Lead Compound 10%
• Nonnucleoside Reverse Transcriptase Inhibitor 10%
• DNA Directed DNA Polymerase 10%
• IC50 10%
• Thymidine Triphosphate 10%