Abstract
The extradiol aromatic ring-cleaving dioxygenases activate molecular oxygen by binding both O2 and the catecholic substrate to a reduced active site metal, generally Fe(II). Progress has been made in understanding the mechanism of this reaction through the combined use of kinetic, computational, biomimetic, structural, and diagnostic chemical approaches. It appears that O2 is activated by accepting an electron transferred from the substrate through the metal, thereby simultaneously activating oxygen and substrate for reaction with each other.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 644-649 |
| Number of pages | 6 |
| Journal | Current Opinion in Structural Biology |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2008 |
Bibliographical note
Funding Information:The author would like to thank many students and collaborators who conducted the studies described here in his laboratory. These studies were supported by National Institutes of Health grant GM24689.