Mechanism of Anti-Complementary Activity of Corticosteroids in Vivo: Possible Relevance in Endotoxin Shock

Joseph T. O'flaherty, Philip R. Craddock, Harry S Jacob

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The effects of several cortico-steroids on the sudden neutropenia which occurs in animals exposed to activated complement components were studied. Solu-Medrol and Solu-Cortef in high concentrations inhibited such neutropenia but only if present before or during the period of complement activation; Decadron was much less efficient. The observed dose and temporal relationships are strikingly similar to those noted in previous studies of corticosteroid protection from endotoxin shock, suggesting that complement-mediated alterations in neutrophils may be critical in this entity. This work was supported in part by grants from the National Institutes of Health, AM 15730, CA 15627, and HL 19725.

Original languageEnglish (US)
Pages (from-to)206-209
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume154
Issue number2
DOIs
StatePublished - Feb 1977

Fingerprint Dive into the research topics of 'Mechanism of Anti-Complementary Activity of Corticosteroids in Vivo: Possible Relevance in Endotoxin Shock'. Together they form a unique fingerprint.

Cite this