TY - JOUR
T1 - Mechanism of Anti-Complementary Activity of Corticosteroids in Vivo
T2 - Possible Relevance in Endotoxin Shock
AU - O'flaherty, Joseph T.
AU - Craddock, Philip R.
AU - Jacob, Harry S
PY - 1977/2
Y1 - 1977/2
N2 - The effects of several cortico-steroids on the sudden neutropenia which occurs in animals exposed to activated complement components were studied. Solu-Medrol and Solu-Cortef in high concentrations inhibited such neutropenia but only if present before or during the period of complement activation; Decadron was much less efficient. The observed dose and temporal relationships are strikingly similar to those noted in previous studies of corticosteroid protection from endotoxin shock, suggesting that complement-mediated alterations in neutrophils may be critical in this entity. This work was supported in part by grants from the National Institutes of Health, AM 15730, CA 15627, and HL 19725.
AB - The effects of several cortico-steroids on the sudden neutropenia which occurs in animals exposed to activated complement components were studied. Solu-Medrol and Solu-Cortef in high concentrations inhibited such neutropenia but only if present before or during the period of complement activation; Decadron was much less efficient. The observed dose and temporal relationships are strikingly similar to those noted in previous studies of corticosteroid protection from endotoxin shock, suggesting that complement-mediated alterations in neutrophils may be critical in this entity. This work was supported in part by grants from the National Institutes of Health, AM 15730, CA 15627, and HL 19725.
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U2 - 10.3181/00379727-154-39638
DO - 10.3181/00379727-154-39638
M3 - Article
C2 - 840858
AN - SCOPUS:0017367165
SN - 0037-9727
VL - 154
SP - 206
EP - 209
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -