Mechanical Ventilation

Mollie M. James, Greg J. Beilman

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The treatment of respiratory failure requiring mechanical ventilation has advanced significantly over the last 20 years. The goal of therapy in patients with acute respiratory distress syndrome should be to optimize oxygenation while minimizing the risk of ventilator-induced lung injury and providing adequate ventilation. Appropriate use of ventilation modes and strategies, positive-end expiratory pressure levels, and recruitment maneuvers can improve oxygen delivery. Salvage therapies, such as prone positioning, inhaled epoprostenol and nitric oxide, and high-frequency oscillatory ventilation, have a well-established role in supportive management and are associated with improved oxygenation but not survival.

Original languageEnglish (US)
Pages (from-to)1463-1474
Number of pages12
JournalSurgical Clinics of North America
Issue number6
StatePublished - Dec 2012

Bibliographical note

Copyright 2013 Elsevier B.V., All rights reserved.


  • ARDS
  • Algorithm
  • Mechanical ventilation
  • Respiratory failure


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