Mechanical stress in tissue-equivalents modulates cell traction

David M. Knapp, Theodore T. Tower, Victor H Barocas, Robert T Tranquillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A study was carried out to quantify simultaneously fibroblast migration and traction. Tissue-equivalent (TE) cylinders were prepared from collagen and human foreskin fibroblast. Compaction of attached and floating TE cylinders were measured and fit with a model. The mechanical stress developed in the attached TE cylinders caused an increase in fibroblast traction but a decrease in migration as compared to floating stress-free TE cylinders, indicating a complex mechanotransduction effect on cell motility.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Other1999 Bioengineering Conference
CityBig Sky, MT, USA


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