TY - JOUR
T1 - Mechanical forces involved in cardiac C-looping
AU - Taber, Larry A.
AU - Voronov, Dmitry A.
AU - Rémond, Mathieu C.
AU - Latacha, Kimberly S.
AU - Alford, Patrick W.
PY - 2004
Y1 - 2004
N2 - Cardiac looping is a vital morphogenetic process that transforms the initially straight heart tube into a curved tube normally directed toward the right side of the embryo. We examined the role of biomechanical forces during the initial stages of looping, when the heart bends and rotates into a c-shaped tube (c-looping). C-looping consists of two primary deformation components: ventral bending and dextral (rightward) rotation (torsion). Embryonic chick hearts were subjected to mechanical and chemical perturbations, and the experiments were simulated using a computational model. The results suggest that bending is driven primarily by actin polymerization within the heart tube, while rotation is driven by external loads due to the splanchnopleure and omphalomesenteric veins. The results of this study may help investigators searching for the link between gene expression and the mechanical processes that drive looping.
AB - Cardiac looping is a vital morphogenetic process that transforms the initially straight heart tube into a curved tube normally directed toward the right side of the embryo. We examined the role of biomechanical forces during the initial stages of looping, when the heart bends and rotates into a c-shaped tube (c-looping). C-looping consists of two primary deformation components: ventral bending and dextral (rightward) rotation (torsion). Embryonic chick hearts were subjected to mechanical and chemical perturbations, and the experiments were simulated using a computational model. The results suggest that bending is driven primarily by actin polymerization within the heart tube, while rotation is driven by external loads due to the splanchnopleure and omphalomesenteric veins. The results of this study may help investigators searching for the link between gene expression and the mechanical processes that drive looping.
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U2 - 10.1115/imece2004-59270
DO - 10.1115/imece2004-59270
M3 - Conference article
AN - SCOPUS:20444465234
SN - 0360-9960
SP - 197
EP - 198
JO - Advances in Bioengineering, BED
JF - Advances in Bioengineering, BED
M1 - IMECE2004-59270
T2 - 2004 ASME International Mechanical Engineering Congress and Exposition, IMECE
Y2 - 13 November 2004 through 19 November 2004
ER -