Mechanical Circulatory Support for Single Ventricle Failure

Massimo Griselli, Raina Sinha, Subin Jang, Gianluigi Perri, Iki Adachi

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Mechanical circulatory support (MCS) for failing single ventricle (SV) physiology is a complex and challenging problem, which has not yet been satisfactorily addressed. Advancements in surgical strategies and techniques along with intensive care management have substantially improved the outcomes of neonatal palliation for SV physiology, particularly for hypoplastic left heart syndrome (HLHS). This is associated with a steady increase in the number of SV patients who are susceptible to develop heart failure (HF) and would potentially require MCS at a certain stage in their palliation. We have reviewed the literature regarding the reported modalities of MCS use in the management of SV patients. This includes analysis of various devices and strategies used for failing circulation at distinct stages of the SV pathway: after neonatal palliation, after the superior cavo-pulmonary connection (SCPC), and after total cavo-pulmonary connection (TCPC).

Original languageEnglish (US)
Article number115
JournalFrontiers in Cardiovascular Medicine
StatePublished - Aug 28 2018

Bibliographical note

Publisher Copyright:
© Copyright © 2018 Griselli, Sinha, Jang, Perri and Adachi.

Copyright 2020 Elsevier B.V., All rights reserved.


  • fontan physiology
  • mechanical circulatory support
  • single ventricle
  • ventricular assist devices

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