Measuring chemotherapy-induced peripheral neuropathy in children: Development of the Ped-mTNS and pilot study results

Laura S. Gilchrist, Lynn Tanner, Mary C. Hooke

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25 Scopus citations

Abstract

The aim of this study was to develop and test the feasibility of a chemotherapy-induced peripheral neuropathy (CIPN) measurement, the ped-mTNS, for use in school-aged children. After adapting an established adult measure (modified-Total Neuropathy Scale), the ped-mTNS was administered one time to 20 children ages 5-18 who were undergoing, or had recently completed, chemotherapy. The ability to complete the measurements, to be understood by school-aged children and represent their symptoms, and the frequency of signs and symptoms was assessed. The ped-mTNS was successfully completed in all children in under 10 minutes. Three children reported symptoms not covered by test items. Sixty percent (12/20) reported sensory symptoms and 55% (11/20) reported motor symptoms. On clinical examination, impairments were found in pin sensibility (30%), vibration (50%), distal muscle strength (90%), and deep tendon reflexes (95%). The mean score was 6.1 ± 3.8 out of possible 24. The ped-mTNS is a feasible measure of CIPN and further research is warranted.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalRehabilitation Oncology
Volume27
Issue number3
DOIs
StatePublished - 2009

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