Measurements of immune responses for establishing correlates of vaccine protection against HIV

Wendy A. Burgers; Amapola Manrique; David Masopust; Lyle R. McKinnon; Matthew R. Reynolds; Morgane Rolland; Catherine Blish; Gerald K. Chege; Rhonda Curran; William Fischer; Carolina Herrera; D. Noah Sather

doi:10.1089/aid.2011.0239

Measurements of immune responses for establishing correlates of vaccine protection against HIV

Wendy A. Burgers
, Amapola Manrique
, David Masopust
, Lyle R. McKinnon
, Matthew R. Reynolds
, Morgane Rolland
, Catherine Blish
, Gerald K. Chege
, Rhonda Curran
, William Fischer
, Carolina Herrera
, D. Noah Sather

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

Original language	English (US)
Pages (from-to)	641-648
Number of pages	8
Journal	AIDS Research and Human Retroviruses
Volume	28
Issue number	7
DOIs	https://doi.org/10.1089/aid.2011.0239
State	Published - Jul 1 2012

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title = "Measurements of immune responses for establishing correlates of vaccine protection against HIV",

abstract = "Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.",

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T1 - Measurements of immune responses for establishing correlates of vaccine protection against HIV

AU - Burgers, Wendy A.

AU - Manrique, Amapola

AU - Masopust, David

AU - McKinnon, Lyle R.

AU - Reynolds, Matthew R.

AU - Rolland, Morgane

AU - Blish, Catherine

AU - Chege, Gerald K.

AU - Curran, Rhonda

AU - Fischer, William

AU - Herrera, Carolina

AU - Sather, D. Noah

PY - 2012/7/1

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N2 - Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

AB - Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

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AN - SCOPUS:84863191097

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JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 7

ER -

Measurements of immune responses for establishing correlates of vaccine protection against HIV

Abstract

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